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I think, however, that we ai-e fully justified in considering a patient cured who has passed through twelve months of immunity, subjected as he is during that time to the various atmospheric changes which are so prone to give rise to an attack, especially during the cold and damp weather of the spring and fall months:

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It was, however, non-pathogenic to if cultivated on streptococcus filtrates, while the Hofniann-Wellenhof bacillus did not. Furthermore, I see no reason for believing that it is ever rarefied for such a length of time as to produce hypenemia of tlie mucous membrane.

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Reduction caused a sharp twinge of pain, followed by immediate relief.